This collaboration has revealed fascinating insights into the botanical complexity of Botaniplex Calm4, including a new role for this unique blend in protecting against UV damage, which was later confirmed by clinical trials.
AI-Predicted Pathways for UV Protection
AI models predict its potential to inhibit cyclophilin D, a protein linked to UV-induced mitochondrial dysfunction, suggesting a role in protecting cellular integrity from UV stress.
MeNow's analysis suggests potential inhibition of nitric oxide synthase (NOS) activity and NOS2 expression, which could reduce UV damage by preventing the formation of harmful radicals.
AI predictions suggest it may stimulate SIRT1 activity, aiding cellular repair, while inhibiting NADPH oxidase to reduce reactive oxygen species generated after UV exposure.
Predicted to inhibit the IL1 pathways, especially crucial in mitigating UV-induced inflammatory responses. This suggests a potential role in curbing skin inflammation triggered by UV radiation.
MeNow’s AI system predicted strong synergistic effects for anti-oxidant activity and the decrease of pro-inflammatory cytokines under UVB radiation. Those results were confirmed by in vitro testing.
This collaboration has revealed Botaniplex Calm4's synergistic protection against UV damage.
MeNow's AI predictions showed the blend inhibits mitochondrial dysfunction, regulates nitric oxide synthase, stimulates cellular repair, and reduces inflammations.
We partnered with KSM66, the biggest supplier of Ashwagandha to analyze the safety profile of the root and the leaf of the plants.
We developed AI models that can predict the liver and reproductive toxicity of individual compounds and blends.
Using this approach, we were able to analyze the safety profile of both plant parts and compare them to other herbal supplements and edible plants.
We leveraged AI to compare the toxicity of Ashwagandha’s root to 331 edible plants and 171 herbal supplements. For nearly all toxicity types, Ashwagandha performed better than the average edible plant or herbal supplement.
Leveraging AI, we identified problematic molecules in the leaves of the plant and compared the safety to other edible and herbal supplements.
During this collaboration, Kamedis used the Search MeNow platform to scan over 25 rare plants from the traditional Chinese pharmacopea. One of the key results of this project was the identification of Angelica sinensis as a potential star for anti-aging.
Active Ingredients Identified:
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A potent, anti-pigmentation agent that inhibits monophenol monooxygenase while scavenging free radicals and obstructing lipid peroxidation.
Not only does it reduce inflammation but it safeguards skin DNA from UV damage.The regulation of CTGF offers an intriguing avenue for boosting collagen production.
Shields against senescence, a crucial facet in combating aging.
With its potential to induce angiogenesis, it opens new doors in skincare innovation.
Holds strong promise in preventing photo-aging and acting as an apoptosis agonist.
We uncovered a remarkable range of anti-aging bioactives in Angelica Sinensis.
This groundbreaking discovery marks a key milestone in skincare, where advanced technologies and scientific methods unlock nature’s remedies to their fullest potential.
Le Soin Du Voyageur serum is the result of synergies between Les Bois's dedication to excellence and Menow's AI capabilities. This resulted to an AI-developed serum with incredible hydration prowess, validated by clinical trials.
We developed an innovative formula in collaboration with Les Bois. It is composed of 7 ingredients with high synergy for Sebum Regulation, Complexion Radiance and Pigmentation Regulation. Double blind clinical validation confirmed the results. This is one of the first instances where a cosmetics formulation was developed using AI.
Using the AI-developed serum led to significantly higher hydration levels versus the levels for control, as predicted by MeNow’s system.
These results open new avenues for the fully automized development of innovative formulations, powered by AI.
